NZ 602024 Disclosed is an anti-CD79b antibody comprising a light chain and a heavy chain comprising hypervariable regions comprising the following sequences disclosed in the specification: (i) HVR-L1 comprising sequence A1-A15, wherein A1-A15 is KASQSVDYSGDSFLN (SEQ ID NO:213) (ii) HVR-L2 comprising sequence B1-B7, wherein B1-B7 is AASNLES (SEQ ID NO: 214) (iii) HVR-L3 comprising sequence C1-C9, wherein C1-C9 is QQSNEDPLT (SEQ ID NO: 215) (iv) HVR-H1 comprising sequence D1-D10, wherein D1-D10 is GYTFSSYWIE (SEQ ID NO: 221) (v) HVR-H2 comprising sequence E1-E18, wherein E1-E18 is GEILPGGGDTNYNEIFKG (SEQ ID NO: 222) (vi) HVR-H3 comprising sequence F1-F10, wherein F1-F10 is TRRVPIRLDY (SEQ ID NO: m223)