An adhesive composition including an adhesive component and an enzymeinhibitingcomponent for use in ostomy and wound care applications. The enzyme inhibitorsarederived from tubers, such as potatoes. In ostomy, the adhesive compositionhelps tosecure the collection bag or pouch to the skin. In wound care application, theadhesivecomposition secures the wound dressing to the skin. The adhesive compositionalsomay be used to couple two or more ostomy or wound care components together.