THE PRESENT INVENTION RELATES TO THE ADENOSINE A3 RECEPTOR LIGANDS OF THE GENERAL FORMULA (I), WITHIN THEM FAVOURABLY TO THE ANTAGONISTS, TO THEIR SALTS, SOLVATES, N-OXIDES AND ISOMERS, TO THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS OF THE GENERAL FORMULA (I), THEIR SALTS, SOLVATES, N-OXIDES AND ISOMERS, TO THE PREPARATION OF THE COMPOUNDS OF THE GENERAL FORMULA (I), THEIR SALTS, SOLVATES, N-OXIDES AND ISOMERS, AS WELL AS TO THE NEW INTERMEDIATES OF THE GENERAL FORMULA (II), (VI), (XI), (XII), AND (XV), AND TO THE PREPARATION THEREOF.