PROBLEM TO BE SOLVED: To provide a therapeutic agent that inhibits TLR9 and exhibits excellent preventive and therapeutic effects against autoimmune diseases, inflammation, allergy, asthma, graft rejection and graft-versus-host diseases (GvHD).SOLUTION: The TLR9-inhibiting agent comprises as an effective ingredient a compound represented by general formula (1) [wherein R1 is a 5- to 7-membered heterocyclic group containing an oxygen atom or a nitrogen atom R2 and R3 are each a 1-10C alkyl group R4 and R5 are each a halogen atom, an amino group, a hydroxy group or a 1-10C alkyl group, and R4 and R5 may be linked together to form a 5- to 7-membered saturated heterocyclic group containing an oxygen atom or a nitrogen atom and n is an integer selected from among 1 to 6].COPYRIGHT: (C)2013,JPO&INPIT【課題】TLR9を阻害し、自己免疫疾患、炎症、アレルギー、喘息、移植片拒絶および移植片対宿主病(GvHD)の予防及び治療効果に優れた治療剤の提供。【解決手段】次の一般式(1):[式中、R1は、酸素原子又は窒素原子を含む5~7員複素環基を示し、R2、R3は、C1-10アルキル基を示し、R4、R5は、ハロゲン原子、アミノ基、水酸基及びC1-10アルキル基を示すか、あるいはR4とR5が、一緒になって酸素原子又は窒素原子を含む5~7員飽和複素環基を形成してもよく、nは、1~6から選ばれる整数を示す。]で表される化合物を有効成分とする、TLR9阻害剤。【選択図】なし
