LES LABORATOIRES SERVIER (SOCIÉTÉ ANONYME);VERNALIS (R&D) LTD.
发明人:
BALZS BLINT,FRANOISE PERRON-SIERRA,GNES PROSZENYK,SZABOLCS SIPOS,GBOR RADICS,LEVENTE ONDI,JAMES BROOKE MURRAY,JAMES EDWARD PAUL DAVIDSON,I CHEN,OLIVIER JEN - GENESTE,ALAIN BRUNO,ANDRS KOTSCHY,ATTILA P
申请号：
ARP160101879
公开号：
AR105101A1
申请日:
2016.06.23
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
This application relates to compounds of thieno [2,3-d] pyrimidin-2-yl useful in Apoptosis and cancer.Claim 1: compounds of formula (1): in which represents the group of formula (2), which is attached to the 1 - and 2 - NH Group attached to the Aromatic Ring； and represents a cycloalkyl Group, a Group heterocicloalquilo,An aryl group or a heteroaryl Group； X represents a nitrogen Atom or group C - r u2074； and represents a nitrogen Atom or group C - r u00b3； r u00b9 represents a Halogen Atom, a linear or branched alkyl group c u2081 u208b u2086 alquenilo c u2082 u208b u2086 Group, a linear or branched, Group a Lquinilo c u2082 u208b u2086 linear or branched, a linear or branched polihaloalquilo c u2081 u208b u2086 Group, a Hydroxy Group.A group hidroxialquilo c u2081 u208b u2086 c u2081 u208b u2086 alkoxy Group, a linear or branched alkyl c u2081 u208b u2086 -, S -, a cyano Group, a Nitro Group, c u2080 u208b u2086 nr u2079r u2079 - alkyl -, - or - c u2081 u208b u2086 nr u2079r u2079 alkyl -, - or - r u00b9 u2070 c u2081 u208b u2086 alkyl, - C (o) - or u2079, - or - C (o) r u2079 -, - C (o) - nr u2079r u2079 nr u2079 -, - C (o) - r u2079, ID u2079 - C (o) - - - nr u2079 c u2081 u208b u2086 or u2079 alkyl, - C (o) - r u2079 nr u2079r u2079 SO u2082 -, -, - SO u2082 alkyl c u2081 u208b u2086； R u00b2, r u00b3, r u2074 r u2075 independently of each other and represent a hydrogen Atom,A Halogen Atom, a linear or branched alkyl group c u2081 u208b u2086 alquenilo c u2082 u208b u2086 Group, a linear or branched, a group Alquinilo c u2082 u208b u2086 linear or branched, a linear or branched polihaloalquilo c u2081 u208b u2086 Group, a Hydroxy Group, a group hidroxialquilo c u2081 u208b u2086, an Alco Group XI c u2081 u208b u2086 linear or branched alkyl c u2081 u208b u2086 -, S -, a cyano Group, a Nitro Group, c u2080 u208b u2086 nr u2079r u2079 - alkyl -, - or - alkyl - nr u2079r u2079 c u2081 u208b u2086,- or - - r u00b9 u2070 c u2081 u208b u2086 alkyl, - C (o) - or u20
