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AGENTS BLOQUANTS NEUROMUSCULAIRES ASYMÉTRIQUES RÉVERSIBLES DE DURÉE ULTRA-COURTE, COURTE OU INTERMÉDIAIRE
专利权人:
Cornell University
发明人:
申请号:
EP13810090.4
公开号:
EP2867219B1
申请日:
2013.06.28
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
We describe ultra-short, short, and intermediate duration neuromuscular blocking compounds, reversible by cysteine or similar compounds, that are bisquaternary diesters of chlorofumaric, fumaric, or maleic acids where the quaternary groups are very different, creating a highly asymmetrical molecule where one quaternary includes an isoquinolinium ring system and the other includes a morpholinium, piperidinium, piperazinium, or pyrrolidinium system, pharmaceutical compositions, methods to use such compounds and compositions, and kits.
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