Methods and apparatus for generating a patient-specific replacement body part. DICOM may be used to describe an anatomical portion of a patient and features may be differentiated that relate to a various biological systems. A user or a controller may designate a portion of features that relate to a biological system to be produced in a tangible model. A data file is generated that represents a surface geometry of a three-dimensional object representative of the portion of the features that relate to the biological system. Fabrication apparatus is operated to produce the object, which includes a tangible three-dimensional model of features that relate to the biological system.