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ВОДНЫЙ ОФТАЛЬМОЛОГИЧЕСКИЙ РАСТВОР НА ОСНОВЕ ЦИКЛОСПОРИНА A
专利权人:
Лаборатуар Теа (FR)
发明人:
МЮРЬО Эммануэль (FR),МЕРСЬЕ Фабрис (FR)
申请号:
RU2014134741
公开号:
RU2014134741A
申请日:
2013.03.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. An aqueous ophthalmic solution comprising: - immunosuppressive agent, preferably cyclosporin A - as first polymer a cellulose derivative, - as a second polyvinyl polymer derivative - as a third polymer is a polymer with a lipophilic functional gruppoy.2. A solution according to claim 1, characterized in that cyclosporin A is at least 0.05 wt.% Solution, preferably from 0.05 to 0.1% .3. A solution according to claim 1, characterized in that it contains no benzalkonium chloride (BAK) .4. A solution according to claim 1, characterized in that it exhibits a Brookfield viscosity at 25 ° C below 50 mPa.s, preferably 5 to 15 mPa · p.5. A solution according to claim 1, characterized in that the cellulose derivative is a cellulose ether, preferably selected from methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, or one of their salts, preferably carboxymethylcellulose natriya.6. A solution according to claim 1, characterized in that the polyvinyl derivative is polyvinyl spirt.7. A solution according to claim 1, characterized in that the polymer having a lipophilic functional group is makrogolglitserina hydroxystearate, preferably makrogolglitserina hydroxystearate 40.8. A solution according to claim 1, characterized in that the cellulose derivative is from 0.1 to 3 wt.% Solution, preferably from 0.5 to 1.5%, more preferably 0.8% .9. A solution according to claim 1, characterized in that the polyvinyl derivative is from 0.25 to 3 wt. % Solution, preferably 0.5% .10. A solution according to claim 1, characterized in that makrogolglitserina hydroxystearate 0,5do ranges from 20 wt.% Solution, preferably from 5 to 15%, even more preferably 10% .11. Unit-dose or mnogodozov1. Водный офтальмологический раствор, содержащий:- иммуносупрессорное средство, предпочтительно циклоспорин A- в качестве первого полимера производное целлюлозы- в качестве второго полимера производное поливинила- в качестве тре
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