PROCÉDÉ DE PRODUCTION DE DÉRIVÉ DE 7H-PYROLLO[2,3-D]PYRIMIDINE ET INTERMÉDIAIRE CORRESPONDANT

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专利权人:

Japan Tobacco; Inc.

发明人:

申请号：

EP16821437.7

公开号：

EP3321271A1

申请日:

2016.07.06

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention provides a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative that is useful as a janus kinase (JAK) inhibitor； an intermediate of the 7H-pyrrolo[2,3-d]pyrimidine derivative； and a method for producing the intermediate. The present invention provides a method for producing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile, which uses a salt of an organic acid and (3S,4R)-3-methyl-1,6-diazaspiro[3.4]octane-1-carboxylic acid benzyl.

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