Stefan H. Bossmann,Deryl L. Troyer,Matthew T. Basel
申请号：
US14605083
公开号：
US09731034B2
申请日:
2015.01.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected visually or using various sensors, and the diagnostic results can be correlated with cancer prognosis.
