Cee, Victor J.,Deak, Holly L.,Du, Bingfan,Geuns-Meyer, Stephanie D.,Hodous, Brian L.,Nguyen, Hanh Nho,Olivieri, Philip R.,Patel, Vinod F.,Romero, Karina,Schenkel, Laurie
申请号：
AU2010241280
公开号：
AU2010241280B2
申请日:
2010.11.05
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2010241280B220130228.pdf#####Abstract The present invention relates to chemical compounds having a general formula (I) wherein A1, A2 , CI, C2 , D, L1 , L2, Z and R' 8 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various 5 disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and method of treating disease states related to the activity of Aurora kinase.
