Artem B. Kutikov,Richard T. Layer,Simon W. Moore,Thomas R. Ulich,Alex A. Aimetti
申请号：
US15362257
公开号：
US20170151286A1
申请日:
2016.11.28
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Injectable mediums and methods for preparing and administering an injectable medium comprising therapeutic cells, and optionally one or more therapeutic or diagnostic substance, suitable for injection into an anatomical space of a human or animal subject, comprising hyaluronic acid in concentrations of 0.5 weight percent to 1.0 weight percent having a molecular weight of about ≧700 kDa to about 1,900 kDa and a storage modulus within the range of 5-25 Pa, which injectable mediums and methods prevent cell settling during transportation and storage of such injectable mediums comprising therapeutic cells, and optionally therapeutic or diagnostic substances promote cell survival facilitate administration of homogeneous injectable mediums comprising therapeutic cells, in particular NSCs and enable rapid clearance by the body following injection, so as not to interfere with cellular integration with surrounding tissue.
