A non-dispersible granular substrate is formed of a plurality of granules, each granule being a mixture including an inert mineral component, a mineral cement, and optionally a light weight additive. The granular substrate could be used, for example, as carriers for pesticides or soil amendments, and as animal bedding (e.g. cat litter). A method of making a non-dispersible granular substrate includes forming a batch mixture including an inert mineral component, a mineral cement, and water, and co-pelletizing the batch mixture to form a plurality of non-dispersible granules.