DR GOVERDHAN PUCHCHAKAYALA,DR KRISHNA MOHAN GOTTUMUKKALA
申请号：
IN2340/CHE/2014
公开号：
IN2014CH02340A
申请日:
2014.05.09
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
ABSTRACT The present invention relates to novel extract for controlling hyperglycaemia and hyperlipidaemia and use for management of diabetes. Aim of the study: To determine the effectiveness of Cipadessa baccifera (CB) extract as an antidiabetic agent in vitro and in vivo. Preparation of Extract: Methanolic extract of CB and its fractions of Cipadessa baccifera. Method: Hypoglycemic effect in normal and antihyperglycemic activityin diabetic rats, cell line(3T3-Ll cells and RIN cells), Rat hemi diaphragm method. Results: The extract have no toxic effect was observed after acute toxicity study and 28 days treatment. In invitro study, Ethyl acetate Fraction of CB (EAFCB) exhibited a concentration dependent free radical scavenging activity. In sub acute study EAFCB showed significantly decreased the elevated levels of blood glucose, cholesterol and trygliserides, SGOT, SGPT and increased the diminished body weight, total protein, insulin in streptozotocin induced diabetic rats, which are desirable in diabetes therapy, in streptozotocin induced diabetic rats, antioxidant activity by significantly decreasing the level of lipidperoxidative marker, malondialdehyde (MDA), a protective action against cell damage required in diabetes therapy. Conclusions: Cipadessa baccifera extract has effects that enhance glucose uptake and provide the basis for antidiabetic activity of the extract.
