Peterson, Ward M.,Watson, Paul S.,Pelz, Nicholas F.,Vittitow, Jason L.,Lampe, John W.,Slade, David J.,Crean, Christopher S.,Decamp, Jonathan Bryan
申请号：
AU2007333715
公开号：
AU2007333715B2
申请日:
2007.12.18
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions.
