Jie Young Song,Ji Yeon Ahn,In Sung Jung,Saelooom Lee,Arang Son,Ky Youb Nam,Hyun Kyung Choi,Seung Yong Seo,Yuan Yue
申请号：
US14591885
公开号：
US09447054B2
申请日:
2015.01.07
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.
