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Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient
专利权人:
发明人:
Jie Young Song,Ji Yeon Ahn,In Sung Jung,Saelooom Lee,Arang Son,Ky Youb Nam,Hyun Kyung Choi,Seung Yong Seo,Yuan Yue
申请号:
US14591885
公开号:
US09447054B2
申请日:
2015.01.07
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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