A fast acting orally disintegrating film (ODF) for administration of local anesthetic for alleviating physical and psychological discomfort in the oral cavity during procedures such as dental procedures or for relieving pain generally such as toothaches. The ODF comprises an active pharmaceutical ingredient such as lidocaine free base or a pharmaceutically acceptable salt thereof in a therapeutically acceptable amount such as about 24 mg, at least one primary hydrophilic film forming polymer, at least one secondary hydrophilic film forming polymer, wherein the ratio of the primary hydrophilic film forming polymer to the secondary hydrophilic film forming polymer is about 1:1 to about 20:1 by weight. The ODF further comprises a plasticizer wherein the ratio of the total weight of primary and secondary hydrophilic film forming polymer to the weight of the plasticizer is about 4:1 to about 4:3.一種用於局部麻醉劑投予之速效口服崩解膜(orally disintegrating film,ODF),在例如牙科處理之過程中用以緩解病人的生理與心理不適或緩解牙痛之疼痛。該ODF包括活性醫藥成分,至少一第一親水性成膜聚合物,至少一第二親水性成膜聚合物,該活性醫藥成分例如利多卡因游離鹽基或是其醫藥上可接受的鹽,其為治療上可接受的量,例如約24mg,其中該第一親水性成膜聚合物與該第二親水性成膜聚合物的比例以重量而言為約1:1至約20:1。該ODF另包括一塑化劑,其中第一與第二親水性成膜聚合物的總重量與該塑化劑的重量之比例為約4:1至約4:3。
