MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
发明人:
SIMON ROSS CRUMPLER,FRANK DR. STIEBER,JULIAN PROF. BLAGG,AURELIE DR. MALLINGER,CHRISTIAN DR. RINK,DENNIS DR. WAALBOER,KAI DR. SCHIEMANN
申请号：
ARP130103891
公开号：
AR093143A1
申请日:
2013.10.25
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Compounds used to treat hyperproliferative diseases such as cancer, inflammation, or degenerative diseases. 1. Claim 1: a formula compound (1),Or the acceptable salts of its stereoisomer or Dow or each of the above isomers, including mixtures in various proportions, wherein R1 is h, La, Hal, CN, s (LA),R2 is h, nh832222,Pull, NH (pull),Hal, x-cyc, R3 is Hal, CN, conh832222,Or R.,R 3. With the C atom attached to it, an asymmetric cycle of 5 or 6 members is formed, which is composed of 1-3 asymmetric atoms selected from O, s and N, and is replaced by 1 or 2 oxo groups. Its heterocycle can also be replaced by Oxo groups. Its heterocycle can form a capacitance ring system with benzene groups. O piridio； r8308es h, La, CONH (LA) or x-cyc； r8309es h, F, or r830808；R83099 forms a heteromorphic period of 5 or 6 members with the atoms attached to it, including 1-3 heteromorphic atoms selected from O, s and N, which are indispensable monkeys,di- o trisustituido de modo independiente con oxo LA NHUh huh.N (LA)Ho (LA) - or Ca； r8310es h, La, Oh or F； CYC is a single cycle, secretory or aromatic variant with 5 or 6 members, consisting of 1-3 heteroatoms selected from O, s and N, which can be replaced by Oxo, La, nh832222 one or two times；Uh huh.N (LA)a. Ho (LA) - or CA only； X is - ch832222；-C₂H₄-,- en...-O - or link； means unbundled or scattered tar containing 1, 2, 3, 4 or 5 carbon atoms, which may be saturated or partially unsaturated, of which 1, 2 or 3 H atoms may be replaced by Hal, and / or 1 ch8322 may be - or--NH-O-SO832222--The Y / O 1 CH group can be replaced by N； CA is a cyclo armour compound with 3, 4, 5 or 6 carbon atoms or cyclo carats, including 3, 4, 5 or 6 carbon atoms and 1 or 2 carbon non cyclo atoms, among which cyclo armour or cyclo carat； 1 ch832222 can be replaced by - O - or 1 ch with N； Hal is f, Cl, Br or I.Compuestos útiles en terapia de enfermedades hiperproliferativas tales como cáncer, enfermedades inflamatorias o degenerativas. Reivindicación 1:
