The present invention relates to a device (1) for stimulating the tracheobronchial air of a patient (5) suffering from an obstructive breathing disorder, which device is capable of modifying the rheology of the tracheobronchial mucus of the patient and includes a negative-pressure generator (6), a physiological interface (2) capable of interfacing the device with the respiratory system of the patient, a connection tube (4) connecting the physiological interface (2) to the negative-pressure generator (6), and a control circuit capable of controlling, by an arrangement during the passive expiration phase, the application of a series of alternating negative-pressure pulses and venting with a predetermined frequency and a predetermined duty factor during a first portion of an expiration cycle and then a second frequency and a second duty factor during a second portion of the expiration cycle, and repeating a predefined number of expiration cycles.
