A secure dispensing device uses biofeedback to control release of a controlled substance. The secure dispensing device includes a housing with an access compartment that holds a controlled substance, the controlled substance including a first amount of the controlled substance to be dispensed according to one or more initial dispensation parameters； a controller that receives prescription bioinformation about a user and processes the prescription bioinformation to determine an adjusted dispensation parameter for the controlled substance to be dispensed, the initial dispensation parameter and the adjusted dispensation parameter of the controlled substance to be dispensed being different； a regulator that releases the controlled substance from within the housing； and an exit path with an opening that is sized for the controlled substance to be released outside of the access compartment.
