A wearable physiological monitoring device is provided. The wearable physiological monitoring device includes a wearable object, a sensing module and a processing module. The sensing module is disposed on the wearable object and is configured to stretch based on a local displacement of target organ of the under-test person contacted by the wearable object to generate a change of a sensing value thereof. The processing module is configured to calculate a physiological changing mode that includes physiological information and occurrence time information based on the change of the sensing value. The physiological information includes a number, duration, a degree or a combination of the above of the stretching of the wearable object to determine the health condition of the under-test person.