The present invention provides adjuvant compositions that are capable of modulating the immune response in a subject including enhancing or suppressing the immune response. These adjuvant compositions may also be used to enhance or suppress the immunogenicity of antigens by enhancing or suppressing antigen presentation activity enhancing or suppressing innate immune responses through activation or suppression of e.g. natural killer cells and/or direct activation of subsets of Band/or T cells. Also provided are methods of making the adjuvant compositions as well as methods of using the adjuvant compositions. In certain embodiments the compositions comprise combinations of the following: a pharmaceutically acceptable carrier a flavonoid a tannin and a vitamin.
