An artificial pancreas system comprising electronic circuitry, a glucose sensor, and an insulin delivery system configured to be placed in the mouth. The artificial pancreas system is configured to measure glucose levels in saliva of the mouth and deliver insulin to the venous system of the mouth. The amount of insulin delivered is a function of the glucose measurement data measured by the glucose sensor. The artificial pancreas system is configured to excite the delivery of insulin ultrasonically and provide electrical stimulation to tissue in the mouth. The artificial pancreas system is configured to form channels in the tissue wherein a portion of the delivered insulin is within the channels in the tissue to be absorbed by the venous system of the mouth.
