A dental hygiene device which comprises first and second spaced fixed elements, a third element interconnected with both said first and second elements to define an opening between said first and second elements within which a dental structure to be flossed is receivable, an elongated cleaning element usable in a flossing operation with first and second longitudinal ends, a first member by which said cleaning element is held and selectively directable from said first element to said second element, and a second member associated with said second element by which said cleaning element is detachably secured. The dental hygiene device is preferably operated by one hand only. In addition, the user can clean the entire mouth using one dental hygiene device.
