Drug delivery device and methods are provided for transdermal drug delivery through a skin. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a first collimator fluidly connected with the gas source adapted to form a first plurality of collimated gas streams comprising the gas. The first collimator has an inlet end and an outlet end. The device further includes a first drug source comprising a drug. The first drug source is configured to release the drug into the first plurality of collimated gas streams between the inlet end and outlet end of the first collimator.
