Yevgeny Brudno,Cathal J. Kearney,Eduardo Silva,Michael Aizenberg,Brian Kwee,Rajiv Desai,Neel S. Joshi,David J. Mooney
申请号：
US15300880
公开号：
US20170119892A1
申请日:
2015.04.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides refillable drug delivery devices. The invention is based in part on the development of systemically administered drug payloads that home to and refill resident, e.g., previously administered/implanted, drug delivery systems, e.g., hydrogel drug delivery systems. In one aspect, the drug delivery depots of the invention are systemically administered, e.g., enterally administered or parenterally administered. The invention provides a method of nanotherapeutic drug delivery, e.g., a DNA nanotechnology-based approach for blood-based drug refilling of intra-tumor drug depots.
