Provided are compositions and methods for filling cells with non-pharmacological dermal fillers leading to smoothened skin wrinkles, augmented lips, improved skin appearance, or treated scars. Additionally, the present disclosure provides a composition comprising a non-pharmacological dermal filler and optionally a pharmaceutically acceptable excipient, the dermal filler being covalently or non-covalently bound to a cell penetrating peptide that is capable to penetrate a dermal cell. In one aspect, the cell penetrating peptide is not longer than about 10 amino acids in length. In another aspect, the cell penetrating peptide is about 7 amino acids in length. In some aspects, the cell penetrating peptide is capable to deliver the dermal filler across a stratum corneumLinvention concerne des compositions et des procédés pour remplir les cellules avec des agents de comblement non pharmacologiques, produisant un lissage des rides cutanées, une augmentation du volume des lèvres, un aspect amélioré de la peau, ou de cicatrices traitées.
