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Substituted 4-aminocyclohexane derivatives
专利权人:
GRÜNENTHAL GMBH
发明人:
NOLTE, BERT,SCHRÖDER, WOLFGANG,LINZ, KLAUS,ENGLBERGER, WERNER,SCHICK, HANS,GRAUBAUM, HEINZ,BRAUN, BIRGIT,OZEGOWSKI, SIGRID,BALINT, JÓZSEF,SONNENSCHEIN, HELMUT
申请号:
ES09725217
公开号:
ES2464102T3
申请日:
2009.03.25
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compound of general formula (2) ** Formula ** where Y1, Y1 ', Y2, Y2', Y3, Y3 ', Y4 and Y4' are selected in each case, independently of each other, from the group formed by -H , -F, -Cl, -Br, -I, -CN, -NO2, -CHO, -R0, -C (>; = O) R0, -C (>; = O) H, -C (>; = O) -OH, - C (>; = O) OR0, -C (>; = O) NH2, -C (>; = O) NHR0, -C (>; = O) N (R0) 2, -OH, -OR0, - OC (>; = O) H, -OC (>; = O) R0, -OC (>; = O) OR0, - OC (>; = O) NHR0, -OC (>; = O) N (R0) 2, -SH , -SR0, -SO3H, -S (>; = O) 1-2-R0, -S (>; = O) 1-2NH2, -NH2, -NHR0, -N (R0) 2, - N + (R0) 3 , -N + (R0) 2O-, -NHC (>; = O) R0, -NHC (>; = O) OR0, -NHC (>; = O) NH2, -NHC (>; = O) NHR0, -NHC (>; = O) N (R0) 2; preferably they are selected in each case, independently of each other, from the group consisting of -H, -F, -Cl, -CN and -aliphatic (C1-8); or Y1 and Y1 ', or Y2 and Y2', or Y3 and Y3 ', or Y4 and Y4' together represent>; = O; Q represents -R0, -C (>; = O) -R0, -C (>; = O) OR0, -C (>; = O) NHR0, -C (>; = O) N (R0) 2 or -C (>; = NH) -R0; R0 represents, in each case, independently, -aliphatic (C1-8), -cycloaliphatic (C3-12), -aryl, - heteroaryl, -aliphatic (C1-8) -cycloaliphatic (C3-12), -aliphatic (C1 -8) aryl, -aliphatic (C1-8) heteroaryl, - cycloaliphatic (C3-8) aliphatic (C1-8), -cycloaliphatic (C3-8) aryl or -cycloaliphatic (C3-8) heteroaryl; R1 and R2, independently of each other, represent -H or -aliphatic (C1-6); or R1 and R2 together form a ring and represent -CH2CH2OCH2CH2-, -CH2CH2NR4CH2CH2- or - (CH2) 3-6-; with the proviso that R1 and R2 do not both represent H at the same time; (Hetero) aryl means heteroaryl or aryl R4 represents, in each case, independently, -H, -R0 or -C (>; = O) R0; n is an integer from 0 to 12; X represents NRA-; RA represents -H or -R0, RB represents -H or -R0, where "aliphatic" is in each case a linear or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon group, unsubstituted or substituted one or more times.Compu
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