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НОВЫЙ РЕЖИМ ПРИЕМА N-ГИДРОКСИ-4-{2-[3-(N, N-ДИМЕТИЛАМИНОМЕТИЛ)БЕНЗОФУРАН-2-ИЛКАРБОНИЛАМИНО]ЭТОКСИ}БЕНЗАМИДА
专利权人:
ФАРМАСАЙКЛИКС ИНК.
发明人:
КЛООС Иоана,РОБЕР Рената,ЖАКЕ-БЕССОН Анне,ДЕПИЛЬ Стефан,ШЕНЕЛЬ Марилор,ФУЛЬЯР Сильвен,БАЛАСУБРАМАНИАН Срирам
申请号:
RU2014113399
公开号:
RU2014113399A
申请日:
2012.09.07
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. N-hydroxy-4- {2- [3- (N, N-dimethylaminomethyl) benzofuran-2-ylcarbonylamino] ethoxy} benzamide of formula (I) or a salt thereof with a pharmaceutically acceptable acid or base, alone or in combination with surgery, chemotherapy, hormonal therapy or radiation therapy, for use in treating cancer, characterized in that it is administered for 4 consecutive days, followed by 3 consecutive days without use, the compounds of formula (I), provided that chemotherapy is not It represents FOLFOX (oxaliplatin / folinic sour a / 5-fluorouracil) .2. A compound of formula (I) according to claim. 1, characterized in that it is used in the form gidrohlorida.3. A compound of formula (I) according to claim. 1 or 2, characterized in that it is administered for 4 consecutive days with the norm 2 doses per day, followed by 3 consecutive days without administration of the compound of formula (I) .4. A compound of formula (I) according to claim. 1 or 2, administered in conjunction with chemotherapy or hormonal therapy or radiation terapiey.5. A compound of formula (I) according to claim. 1 or 2 for use in treating carcinomas, tumors, neoplasms, lymphomas, melanomas, gliomas, sarcomas or blastomy.6. A compound of formula (I) according to claim. 1 or 2 for use in treating solid opuholey.7. A compound of formula (I) according to claim. 1 or 2 for use in treating breast cancer zhelezy.8. A compound of formula (I) according to claim. 1 or 2 for use in the treatment of epithelial ovarian carcinoma, carcinoma of the fallopian tube, or primary peritoneal kartsinomy.9. A compound of formula (I) according to claim. 1 or 2, characterized in that the chemotherapy is cisplatin, doxorubicin or pegilirovannыy liposomnыy doksorubitsin.10. Soedineniy formulы (I) by n. 1-yl1. N-гидрокси-4-{2-[3-(N,N-диметиламинометил)бензофуран-2-илкарбониламино]этокси}бензамид формулы (I)или его соли присоединения с фармацевтически приемлемой кислотой или основанием, отдельно или в сочетании с хирургическим вмешательст
来源网站:
中国工程科技知识中心
来源网址:
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