8-PHÉNYL-ISOQUINOLINES ET COMPOSITION PHARMACEUTIQUE ASSOCIÉES UTILISÉES DANS LE TRAITEMENT DU SYNDROME DU CÔLON IRRITABLE

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专利权人:

National Taiwan University

发明人:

HSIN, Ling-Wei,LEE, Tsung-Chun,YU, Linda Chia-Hui

申请号：

EP18760476

公开号：

EP3589626A4

申请日:

2018.03.02

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

A series of 8-phenyl-isoquinoline derivatives (I) exhibit high binding affinity to 5-HT7 receptor (5-HT7R) and demonstrate potent antinociceptive activity in two animal models for Irritable Bowel Syndrome (IBS) by intraperitoneal injection (i.p.) or by oral administration (p.o.). These 5-HT7 receptor antagonists are a new class of therapeutic agents for the treatment of IBS.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/