Extemporaneous Preparation of Autologous Fibrin Autologous fibrin is prepared extemporaneously from either a full blood sample or a prepared sample of poor platelet plasma where in the latter is subject to a dedicated treatment and combined isolation process performed by means of a removable single-use device (2) wherein blood or plasma components are separated and subsequently treated individually to be eventually combined by the user outside the system. The said system comprises a platform (1) and a removable single-use device both being designed to cooperate mechanically.