Provided herein are compositions, systems, kits, and methods for treating cancer by administering to a subject an agent that inhibits a target mRNA or target protein selected from ROR2, JNK1, LCK, LIME, BRCA1, and MLH1. In certain embodiments, the cancer is a uterine or ovarian cancer. In some embodiments, the cancer is chemotherapy refractory cancer (e.g., Cisplatin resistant cancer). In particular embodiments, the subject is further administered an anti-cancer agent (e.g., the agent sensitizes the cancer cells to treatment with an anti-cancer agent, such as Cisplatin).
