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UTILISATION D'ENZYMES HYDROLYTIQUES POUR DISSOUDRE UN BIOFILM DANS LES OREILLES
专利权人:
Laclede; Inc.
发明人:
申请号:
EP15167603.8
公开号:
EP2939687A1
申请日:
2007.11.07
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
A composition for removal of biofilm in the ears is useful for the treatment of ear infections such as otitis media, particularly those infections caused by Pseudomonas aeruginosa. In general, the composition comprises: (1) a quantity of at least one enzyme that catalyzes the hydrolysis of a bond that connects two monosaccharides in a polysaccharide or that connects a monosaccharide with a protein molecule in a glycoprotein sufficient to break down biofilm in the ear; and (2) a pharmaceutically acceptable carrier suitable for administration into the ear canal. The composition can further include ingredients such as a steroid, lysozyme, lactoferrin, or a peroxidase; if a peroxidase is included, the composition can further include an oxidase to generate peroxide as well as a substrate for the oxidase. The composition can be used in methods for treatment of an ear infection based on the ability of the composition to dissolve biofilm in the ear.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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