1. Application:! (i) a DNA sequence selected from a group of sequences that encode a peptide whose amino acid sequence is selected from:! a) SEQ ID NO: 1 or a peptide that is at least 90% homologous to the indicated sequence and having immunomodulatory activity, or a fragment thereof having immunomodulatory activity； ! b) SEQ ID NO: 2 or a peptide that is at least 90% homologous to the sequence with immunomodulating activity, or a fragment thereof having immunomodulating activity； ! c) SEQ ID NO: 3； ! d) SEQ ID NO: 4； and! e) SEQ ID NO: 5； or ! (ii) an expression system containing said DNA sequence! for preparing a pharmaceutical composition for regulating a humoral immune response, or for regulating a cellular immune response, or for regulating both a humoral immune response and a cellular immune response； or ! for preparing a pharmaceutical composition for treating a pathology selected from a pathology associated with microorganisms that induce TGF-β1 mediated immunosuppression and cancer； or ! as an adjuvant for vaccination. ! 2. The use according to claim 1 after immunization to protect against tumor growth. ! 3. The use according to claim 1 in a mixture for immunization with an antigen to inhibit a humoral immune response. ! 4. The use according to claim 1 for the stimulation of antigen-presenting cells. ! 5. The use according to claim 1, where the specified microorganism is selected from the group consisting of Leishmania sp., Trypanosoma cruzi, human immunodeficiency virus (HIV), influenza virus and herpes simplex virus (HSV). ! 6. The use according to claim 1, where the specified cancer is selected from breast cancer1. Применение: ! (i) последовательности ДНК, выбранной из группы последовательностей, которые кодируют пептид, аминокислотная последовательность которого выбрана из: ! a) SEQ ID NO: 1 или пептида, гомологичного указанной последовательности по крайней мере на 90% и обладающего иммуномодулирующей активностью, или их фрагмента, обладающего иммуном
