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Bosutinib forms and preparation methods thereof
专利权人:
发明人:
Padiyath Mohammed Akbarali,Venkata Ramana Kintali,Heggadde Nanjunda Bhatta Shreenivasa Murthy,Girisha Meenkere,Somanath Bhupal Venkata,Raja Ramesh Manda,Vishal Amrutlal Sodha,Abbulu Kante
申请号:
US15120226
公开号:
US09776970B2
申请日:
2015.02.20
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present subject matter relates to solvates and the amorphous form of bosutinib the solvates namely being a propylene glycol solvate and an acetonitrile solvate. Also provided are processes for preparing the propylene glycol solvate, the amorphous form and the crystalline acetonitrile solvate of bosutinib as well as compositions comprising said forms. Bosutinib is a 3-quinolinecarbonitrile kinase inhibitor and is indicated for the treatment of adult patients with chronic, accelerated, or blast phase Ph+ chronic myelogenous leukemia (CMS) with resistance or intolerance to prior therapy.
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