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COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISEASES
专利权人:
CASE WESTERN RESERVE UNIVERSITY
发明人:
Krzysztof Palczewski,Radu Moise
申请号:
US13679592
公开号:
US20130072555A1
申请日:
2012.11.16
申请国别(地区):
US
年份:
2013
代理人:
摘要:
In one aspect of the present invention, a pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of (R)-all-trans-13,14-dihydroretinol and a pharmaceutically acceptable carrier or diluent. In another aspect of the present invention, pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of (S)-all-trans-13,14-dihydroretinol and a pharmaceutically acceptable carrier or diluent. In a further aspect of the present invention, a method is provided for treating a metabolic disease in a mammalian subject. The method includes administering to the subject a pharmaceutical composition comprising at least one all-trans-13,14-dihydroretinoid, all-trans-13,14-dihydroretinoid derivative, or agent capable of modulating the level of at least one all-trans-13,14-dihydroretinoid or all-trans-13,14-dihydroretinoid derivative in the subject.
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