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Genetically modified non-human animals and methods of use thereof
专利权人:
Regeneron Pharmaceuticals, Inc.;Yale University;Institute for Research in Biomedicine (IRB)
发明人:
Richard Flavell,Till Strowig,Markus G. Manz,Chiara Borsotti,Madhav Dhodapkar,Andrew J. Murphy,Sean Stevens,George D. Yancopoulos
申请号:
US14072626
公开号:
US09901082B2
申请日:
2013.11.05
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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