Disclosed are Nogo receptor proteins and biologically active Nogo (ligand)protein fragments. Also disclosed are compositions and methods for modulatingthe expression or activity of the Nogo and Nogo receptor protein. Alsodisclosed are peptides which block Nogo-mediated inhibition of axonalextension. The compositions and methods of the invention are useful in thetreatment of cranial or cerebral trauma, spinal cord injury, stroke or ademyelinating disease.
