The invention is in the field of antibodies useful in therapeutic and diagnostics applications targeting CD127, the alpha chain of the IL7 receptor, and provides in particular humanized monoclonal antibodies against CD127, particularly human CD127, therapeutic uses thereof, and diagnostics applications.本發明係屬用於治療和診斷應用之靶向CD127(IL7受體之α鏈)之抗體的領域且特別是提供針對CD127(特別是人CD127)之人化單株抗體、該人化單株抗體之治療用途及診斷應用。