sulphur glycosaminoglycans, including heparin, low molecular weight heparin and their derivatives, for use in the therapeutic treatment of anaemias and for the inhibition of the expression of epcidina.
UNIVERSITA' DEGLI STUDI DI BRESCIA;UNIVERSITA DEGLI STUDI DI BRESCIA
发明人:
AROSIO PAOLO,POLI MAURA
申请号：
ITTO20090940
公开号：
IT1397285B1
申请日:
2009.12.01
申请国别(地区):
IT
年份:
2013
代理人:
摘要：
The invention relates to a new medical application of sulphated glycosaminoglycans, particularly heparin, low molecular weight heparin and derivatives thereof, in the therapeutic treatment of anaemia, in particular iron deficiency anaemia, chronic disease anaemia (also known as inflammatory anaemia) and iron-refractory iron-deficient anaemia (IRIDA). The mechanism underlying the new medical application is the ability of the aforementioned sulphated glycosaminoglycans to inhibit or reduce the levels of expression of hepcidin, a hepatic molecule which plays a central role in regulating systemic iron homeostasis.
