Brian L. Hodous,Lesley Liu-Bujalski,Reinaldo Jones,Donald Bankston,Theresa L. Johnson,Igor Mochalkin,Ngan Nguyen,Hui Qiu,Andreas Goutopoulos,Nadia Brugger
申请号：
US15417953
公开号：
US10016448B2
申请日:
2017.01.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
