We report method of detecting a pathological body state of a patient, comprising receiving a body signal of the patient； determining a body index from said body signal； determining an activity level of said patient； determining a value range for said body index for said patient, based at least in part on said activity level； comparing said body index to said value range； and detecting a pathological state when said body index is outside said value range. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
