A device for combined optical and nuclear image comprises a nuclear image acquisition module and a reference image acquisition module. The reference image acquisition module has: an optical image sensor and an optical imaging system for deflecting the optical radiation from a reference field of view to the image sensor, wherein the optical imaging system comprises a mirror for the optical radiation, which mirror is arranged between the reference field of view and the optical image sensor. On the image sensor, a respective image area assigned to at least one of nuclear partial fields of view. The optical imaging system is arranged such that the optical radiation coming from the at least one nuclear partial field of view is deflected substantially exactly to the respectively assigned of the image areas.