RÖSCH Esther,HOELIG PETER,LINDLEY DAVID J,SANZGIRI YESHWANT D,TONG PING
申请号：
IN2738/CHENP/2013
公开号：
IN2013CN02738A
申请日:
2013.04.09
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
A pro apoptotic solid dispersion comprises in essentially non crystalline form a Bcl 2 family protein inhibitory compound of Formula I as defined herein dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises subjecting to elevated temperature the compound of Formula I the water soluble polymeric carrier and the surfactant to provide an extrudable semi solid mixture extruding the semi solid mixture and cooling the resulting extrudate to to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti apoptotic Bcl 2 family proteins for example cancer or an immune or autoimmune disease.
