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Process For Preparing 5-Hydroxyalkyl-Substituted 1-Phenyl-1,2,4-Triazole Derivatives
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
SCHIRMER, Heiko,RUBENBAUER, Philipp,MILITZER, Hans-Christian,COLLIN-KRÖPELIN, Marie-Pierre,SÜSSMEIER, Frank,GERICKE, Kersten,NEUBAUER, Thomas,FÜRSTNER, Chantal
申请号:
SG11201809672Y
公开号:
SG11201809672YA
申请日:
2017.05.02
申请国别(地区):
SG
年份:
2018
代理人:
摘要:
Process for preparing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4-triazole derivatives The present application relates to a novel and improved process for preparing 5- (hydroxyalkyl)-1-pheny1-1,2,4-triazole derivatives of the formula (I) HO OHO,,F / N—N N R IAIF 1B d ilk R CI (I) 5 in which RIA and RIB are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl, monofluoromethyl, difluoromethyl, trifluoromethyl, ethyl, methoxy, difluoromethoxy and trifluoromethoxy, to novel precursors for preparation thereof, and to the preparation and use of the crystalline 10 polymorph I of (5-(4-chloropheny1)-24(1-(3-chloropheny1)-5-[(1 S)- 1-hydroxyethy1]-1H- 1 ,2,4-triazol-3 -yl}methyl)-4-[(28)-3,3,3 -trifluoro-2-hydroxypropy1]-2,4-dihydro-3 H- 1,2,4 - triazol-3 -one of the formula (I-A-1). No suitable figure
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