NOUVEAUX EPITOPES DES LYMPHOCYTES T CYTOTOXIQUES DU CYTOMEGALOVIRUS HUMAIN (HCMV), POLYEPITOPES, COMPOSITIONS COMPRENANT CES DERNIERS ET UTILISATIONS DIAGNOSTIQUES, PROPHYLACTIQUES ET THERAPEUTIQUES CORRESPONDANTES
THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
发明人:
申请号：
EP02737666.4
公开号：
EP1409527B1
申请日:
2002.06.26
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention provides CTL epitope peptides and polyepitope peptides from 14 distinct antigens of human cytomegalovirus (HCMV) that are restricted through HLA the must commonly prevalent class I alleles in different ethnic populations of the world. These epitopes provide an important platform for CTL epitope-based vaccines against HCMV. The present invention further provides vaccine compositions comprising the subject epitope and polyepitope peptides and methods for vaccination of humans and for the adoptive transfer of HCMV-specific T cells to human subjects. The present invention further provides reagents and methods for determining the HCMV status or level of HCMV-specific immunity of a subject.
