YEDA RESEARCH AND DEVELOPMENT CO. LTD.;SCHERZ, AVIGDOR;BRANDIS, ALEXANDER;MAZOR, OHAD;SALOMON, YORAM;SCHEER, HUGO
发明人:
SCHERZ, AVIGDOR,BRANDIS, ALEXANDER,MAZOR, OHAD,SALOMON, YORAM,SCHEER, HUGO
申请号：
CA2506296
公开号：
CA2506296C
申请日:
2003.11.17
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention provides anionic water-soluble tetracyclic and pentacyclicbacteriochlorophyll derivatives (Bchls) containing at least one, preferablytwo or three, negatively charged groups and/or acidic groups that areconverted to negatively charged groups at the physiological pH, preferablyBchls having a group COO-, COS-, SO3-, PO32-, COOH, COSH, SO3H, and/or PO3H2bound through an ester or amide bond to one or more of the positions 173, 133,and 32 of the tetracyclic or pentacyclic Bchl molecule, for photodynamictherapy and diagnosis.
