TRANTER, Michael,ANTHONY, Sarah,SLONE, Samuel,HE, Jie,YOSHIDA, George,GABANIC, Andrew
申请号：
EP17779734
公开号：
EP3440462A4
申请日:
2017.04.05
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Methods for the treatment of cardiac hypertrophy are described. Additionally, the presently disclosed subject matter relates to the use of small molecule compounds for the inhibition of Human antigen R (HuR)-mRNA interaction, and more particularly for the reduction nuclear factor of activated T cells (NFAT) transcriptional activity. Novel methods of screening for small molecule compounds for inhibition of RNA binding proteins interaction with their target RNA (such as HuR-mRNA interactions) or for inhibition of DNA binding proteins to their target DNA are also described.
