Peter Ellmark,Sara Fritzell,Christina Furebring,Jessica Petersson,Anna Sall,Karin Enell Smith,Laura Varas,Laura Von Schantz,Niina Veitonmaki
申请号:
US16514374
公开号:
US20190352414A1
申请日:
2019.07.17
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with binding specificity for domain 2 of human CD137 which are capable of inhibiting the binding of a reference antibody to human CD137. The antibodies and fragments have utility in the treatment of diseases such as cancer. The invention also relates to pharmaceutical compositions, uses, methods and kits comprising such antibodies.