Quaternized buprenorphine analogs

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专利权人:

Purdue Pharma L.P.

发明人:

Kyle, Donald J.

申请号：

AU2012324012

公开号：

AU2012324012A1

申请日:

2012.12.07

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2012324012A120130627.pdf#####ABSTRACT The present invention is directed to Buprenorphine Analog compounds of the Formula I, Formula IA or Formula IB shown below, wherein R , Ria, R2, R', Rla, Rlb G, X, Z, Y, and A ED are as defined herein. AP RR Ae RI R 1-a Rla R31 RaG Rab G R2 Z G R Z Y 8 R8 (IA) (I)B AP R1 :kR38.,R3b ZG R2 X R (mB) Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.

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